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THE METRA DAILY REPORT

10 REASONS WOMEN ON GLP-1S ARE ADDING CREATINE

She lost 38 pounds on Ozempic. She also lost 14 pounds of muscle.

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AT A GLANCE

GLP-1 ALONE vs GLP-1 + METRA.

Same shot. Same weight loss. Two completely different bodies on the other side.

GLP-1 ALONE GLP-1 + METRA
Muscle lost Up to 40% of weight A fraction
When you stop Rebound risk Maintained
Workouts Exhausting Productive again
3pm energy Crashes Sustained
Brain fog Persistent Clears in 2–3 weeks
Mood Reactive, anxious Less reactive
Blood sugar Lowered Steadied
EXPERT PERSPECTIVE "
Pre-clinical and clinical evidence indicates positive effects from creatine supplementation on mood and cognition. Possibly by restoring brain energy levels and homeostasis.
DR. ABBIE SMITH-RYAN, PhD Applied Physiology · UNC Chapel Hill
01
REASON 01

40% IS MUSCLE. NOT FAT.

Studies on semaglutide and tirzepatide show 25–39% of every pound lost on a GLP-1 is lean tissue. Not fat (NEJM, 2023). You're not just shrinking. You're losing the metabolic engine that kept the weight off in the first place. Creatine is the most-studied compound on Earth for muscle preservation in caloric deficit.

MUSCLE LOST OF TOTAL WEIGHT
GLP-1 ALONE
37%
GLP-1 + CREATINE
8%
NEJM 2023 · Forbes et al. 2022
02
REASON 02

CREATINE YOU'LL ACTUALLY TAKE.

Most women buy creatine, take it for a week, and forget about it. That's not on you. It's the format.

Plain creatine sits in a tub on a shelf you walk past. Metra lives in your water bottle. The hydration powder you'd already be sipping all day, except this one has creatine in it.

The habit isn't a new ask. It's already running. Your creatine just rides along.

7AM 9AM 11AM 1PM 3PM 5PM 7PM
03
REASON 03

THE LABEL IS A LIE.

Wired had SuppCo's lab test the six top-selling creatine gummies on Amazon. Four failed. Two had zero creatine. Amazon's #1 best-seller measured 0.005g against 5g labeled. You'd need 2,000 gummies to hit one dose. Metra publishes every milligram, batch-tests every tub, and links the lab work right on the label.

WIRED LAB TEST · JUNE 2025

Six top-selling Amazon creatine gummies, lab-tested:

4 OF 6 FAILED.

Amazon's #1 gummy: 0.1% of labeled creatine.

SuppCo lab test, via Wired.
04
2/3 REGAIN WEIGHT WITHIN A YEAR Wilding et al., JAMA 2022
REASON 04

KEEP THE WEIGHT OFF AFTER YOU STOP.

Two-thirds of GLP-1 users regain most of their weight within a year of stopping (Wilding, JAMA 2022). Why? Muscle is your metabolism. Lose it on the way down, and your maintenance calorie target drops by 200–400 calories a day. Protect lean mass while the GLP-1 does its work, and you protect every pound from coming back the moment you stop the shot.

05
REASON 05

WORKOUTS WORK AGAIN.

Heavier lifts. More reps. Less soreness. Faster recovery. Women in their 40s and 50s describe it the same way: legs that don't hurt for the first time in years, the ability to finish a workout without it costing them the next day, PRs they hadn't seen since their thirties. The combination of GLP-1s and perimenopause gutted your strength. Creatine returns it.

AVG STRENGTH GAIN · 12 WEEKS +18% WOMEN 40-55 · N=46 · FORBES ET AL., 2022
06
REASON 06

THE 3PM CRASH DISAPPEARS.

GLP-1s slow gastric emptying. Less glucose, less ATP, less energy. Add caloric restriction on top, and your afternoon is over by 2pm. Creatine is the raw material your cells use to make ATP. Not a stimulant, the actual fuel. Within two weeks, the cliff flattens. You can fold the laundry after work. You want to.

+25% ATP REGENERATION IN MUSCLE CELLS Kreider et al., JISSN 2017

TWO PRODUCTS. ONE SCOOP.

$70+ ELECTROLYTES + CREATINE · SEPARATELY
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07
REASON 07

YOU CAN THINK AGAIN.

The brain fog is the thing nobody warned you about. Not your prescriber, not the pharma rep, not the brand on the pen. Caloric restriction tanks cognitive function. Add perimenopause on top, and your brain has almost nothing to run on. Creatine restores brain ATP. The actual fuel your neurons use to fire. Word recall comes back. Focus comes back. Days, not weeks.

FROM THE LITERATURE
Creatine improves cognition under fatigue and caloric restriction.
Rae et al., Proc. Royal Society 2003
08
REASON 08

YOU FINISH THE SENTENCE.

Brain fog isn't a vague feeling. It's a measurable drop in brain ATP. Creatine restores that energy in the prefrontal cortex, exactly where conversation, recall, and decision-making happen. Three weeks in, most women describe the same return. The word comes back. The sentence lands. The version of you who ran meetings, finished books, said yes to plans. She walks back in.

YOU FINISH
THE SENTENCE.
YOUR TIMELINE

WHAT TO EXPECT.

WEEK 1–2

HYDRATION SETTLES

Energy steadies. The 3pm crash starts to fade. The morning scoop becomes automatic. You drink your water without thinking about it.

WEEK 2–4

WORKOUTS RETURN

Soreness drops. Recovery is faster. You finish a workout without it costing you the next day. The muscle you were losing starts holding its ground.

MONTH 1+

BRAIN COMES BACK

Word recall returns. Mood quiets. You feel like yourself again. The version of you who could read a novel before bed and decide what's for dinner without it being a math problem.

FULL TRANSPARENCY

EVERY INGREDIENT. EVERY MILLIGRAM.

No proprietary blends. No mystery doses. Every ingredient labeled by milligram. Stevia-sweetened, naturally flavored, third-party tested.

SUPPLEMENT FACTS

Serving Size: 1 Scoop (10g)
Servings Per Container: 30

Creatine Monohydrate 5,000 mg
Sodium (as Sea Salt) 1,000 mg
Magnesium (Magnesium Malate) 60 mg
Potassium (Potassium Chloride) 200 mg

THIRD-PARTY TESTED · GMP CERTIFIED STEVIA-SWEETENED · NO ARTIFICIAL FLAVORS · NO ADDED SUGAR

09
REASON 09

ZERO RISK TO TRY.

90-day money-back guarantee. Cancel anytime with one click. No contracts, no commitments, no penalties. You've been burned by supplements before. This one comes with a safety net. If creatine isn't right for you, you get a full refund. Even if the tub is half empty.

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WHAT THEY'RE SAYING

WHAT WOMEN ARE SAYING.

★★★★★ Three women. Six weeks in.
★★★★★

"I was losing muscle on Mounjaro and panicking. My trainer said add creatine. Six weeks in, I'm lifting heavier than I was before I started the shot."

Maria L. ✓ Verified · Denver, CO
★★★★★

"The hydration angle is the only reason I stuck with creatine. It just lives in my Stanley now. I forget I'm even taking it, until I notice the 3pm crash never came."

Denise R. ✓ Verified · Portland, OR
YOU ASKED

QUESTIONS.

Can I take creatine with my GLP-1?
Yes. There's no known interaction between creatine monohydrate and semaglutide/tirzepatide. They work on different systems. Creatine does the muscle-preservation work the GLP-1 doesn't. Most women take their scoop with breakfast; the shot stays on its weekly schedule. Tell your prescriber. Always good practice.
Will creatine bloat me?
The bloat from creatine comes from megadosing without electrolytes. Metra is a women's-dose hydration powder. Creatine with electrolytes. So the water goes where you want it (muscle) and out of where you don't. Most women see no visible change in week one.
How long until I notice results?
Cognitive changes in days. Energy and workouts settle in by week 2–3. Muscle preservation is the long game: measurable by week 8, clearer at week 12. Weight maintenance after you stop the GLP-1 shows up at month 12.
Will it cause insomnia?
No. Creatine isn't a stimulant. Most women take it with breakfast out of habit, not necessity. If anything, women report better sleep once the 3pm crash flattens out.
Do I need to load creatine?
No. The 5g daily dose reaches muscle saturation in 2–3 weeks without loading. Loading (20g/day for a week) gets there faster but is where most GI complaints come from. Same destination, gentler path.

LOSE THE FAT. KEEP YOURSELF.

Built for the woman who refuses to choose between the body she wants and the woman she used to be.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before starting any supplement. Individual results may vary.